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应用聚合酶链反应（ＰＣＲ），检测了１０６例正常汉族人及５５例缺血性脑血管病（ＩＣＶＤ）病人的ａｐｏＢ基因ｘｂａⅠ酶切位点限制性片段长度多态性（ＲＦＬＰｓ）及其与血脂的关系。结果表明ＩＣＶＤ组ｘｂａⅠ酶切位点上Ｘ＋的等位基因频率明显高于正常对照组（Ｐ＜０．００５）；ＩＣＶＤ组中具Ｘ＋Ｘ－基因型者的血浆ＨＤＬ－Ｃ较Ｘ－Ｘ－基因型者明显降低（Ｐ＜０．０５），而ＬＰ（ａ）和ＴＣ明显增高（Ｐ＜０．０５～０．００５）。提示ａｐｏＢ基因多态分析结合血浆脂蛋白测定更能有效地检测ＩＣＶＤ易患人群。
Polymerase chain reaction (PCR) was used to detect restriction fragment length polymorphisms (RFLPs) of apoB gene in 106 normal Han and 55 patients with ischemic cerebrovascular disease (ICVD) The relationship between blood lipids. The results showed that the frequency of X + alleles in Xba Ⅰ site of ICVD group was significantly higher than that of the normal control group (P <0.005). The plasma HDL-C levels of X + X- genotypes in ICVD group were significantly higher than those in X-X- (P <0.05), while LP (a) and TC were significantly increased (P <0.05 ~ 0.005). Tip apoB gene polymorphism combined with plasma lipoprotein assay more effectively detect ICVD susceptible population.