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在过去的几十年中,新生儿缺氧缺血性脑病(HIE)损伤后神经保护和神经康复的临床和基础研究取得了巨大进步。然而,就新生儿特异性的神经保护措施方面,除亚低温治疗已广泛应用于临床外[1-2],其他治疗措施距离临床推广应用尚有一段距离,不同学者持有许多不同的观点,因此,神经保护策略仍然需要更深入的研究[3]。由于HIE发生发展是一个渐进的过程,根据其所处阶段不同,其治疗靶点也不尽相同,如何确定最佳的治
In the past few decades, clinical and basic research on neuroprotection and neurorehabilitation after neonatal hypoxic-ischemic encephalopathy (HIE) has made great strides. However, in terms of neonatal specific neuroprotective measures, except mild hypothermia has been widely used in clinical practice [1-2], other treatment measures are still some distance from the clinical application of promotion, different scholars hold many different views, Therefore, neuroprotective strategies still need further study [3]. As the development of HIE is a gradual process, according to their different stages, the therapeutic target is not the same, how to determine the best governance