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目的:分析兰州市健康人群乙型肝炎病毒(HBV)血清流行病学特征,为乙肝的预防和治疗提供流行病学依据。方法:对来我院体检中心健康查体的9036例检查者(男5363例,女3673例)采用酶联免疫吸附试验(ELISA)测定5项HBV血清标志物,根据检测结果分为正常组8048例和感染组988例,分析HBsAg阳性模式及其他感染模式分布,并比较不同性别HBV血清标志物检出情况。结果:9036例中,正常组中5项全阴2302例,占25.48%;单项抗-HBs阳性5746例(其中,曾经接种乙肝疫苗398例),占63.59%。感染组中,HBsAg阳性共289例,占3.20%,其中男性阳性率3.75%,非常显著高于女性的2.40%(P<0.01);其他感染模式699例,占7.73%,其中男性阳性率8.71%,非常显著高于女性的6.31%(P<0.01)。结论:本次体检的9036例HBV感染率为10.39%,其中,HbsAg阳性携带感染率为3.20%,低于我国成年人乙肝病毒携带率。
Objective: To analyze the epidemiological characteristics of hepatitis B virus (HBV) in healthy population of Lanzhou City and provide epidemiological basis for the prevention and treatment of hepatitis B. Methods: Nine hundred and seventy-six check-ups (5363 males and 3673 females) who came to our hospital for physical examination were enrolled in the study. Five serum HBV markers were detected by enzyme linked immunosorbent assay (ELISA), and were divided into normal group 8048 Cases and infection group 988 cases, analysis of HBsAg positive patterns and other infection patterns distribution, and compared different gender HBV serum markers detected. Results: Of the 9036 cases, 5 cases of all overcast in the normal group were 2302 cases, accounting for 25.48%; 5746 cases of single anti-HBs positive (of which 398 cases had been vaccinated hepatitis B vaccine) accounted for 63.59%. In the infection group, there were 289 cases (3.20%) positive for HBsAg, the positive rate was 3.75% in male and 2.40% in female (P <0.01). Other infection patterns were 699 (7.73%), of which the positive rate was 8.71 %, Which was significantly higher than that of women (6.31%, P <0.01). Conclusion: The prevalence of 9036 cases of HBV infection in this examination was 10.39%. Among them, the positive rate of HbsAg carrier was 3.20%, which was lower than that of our country.