来曲唑作为第三代芳香化酶抑制剂,已经在肿瘤领域得到应用。近来越来越多研究表明来曲唑在妇产科临床亦有广泛应用前景。来曲唑通过抑制雌激素生物合成,阻断雄烯二酮及睾酮向雌激素的转化,降低体内雌激素水平,但不影响其他甾体激素生物合成。在卵泡早期能刺激卵泡刺激素释放,促进卵泡发育和排卵。对盆腔子宫内膜异位症和子宫肌瘤亦有良好治疗效果。 Letrozole, a third-generation aromatase inhibitor, has been used in the field of oncology. Recently, more and more studies have shown that letrozole in the clinical obstetrics and gynecology is also widely used. Letrozole inhibits estrogen biosynthesis, blocks the conversion of androstenedione and testosterone to estrogen, and decreases estrogen levels in the body, but does not affect other steroid hormone biosynthesis. In the early follicle can stimulate follicle-stimulating hormone release, promote follicular development and ovulation. Pelvic endometriosis and uterine fibroids also have good therapeutic effect.