目的研究生长激素（ＧＨ）和胰岛素样生长因子（ＩＧＦｓ）对小儿免疫系统发育的调节作用及其机制。方法采用放射受体竞争结合、核酸分子杂交、免疫组化等方法，从蛋白质和（或）基因表达水平系统观察了ＧＨ及其受体（ＧＨＲ）、ＩＧＦ多肽（ＩＧＦＩ、Ｉ）、受体（ＩＧＦＩＲ、ＩＲ）和结合蛋白（ＩＧＦＢＰ１６）在小儿外周血淋巴细胞（ＰＢＬ）、胸腺和淋巴结的表达、分布与调节。结果ＧＨＲ在ＰＢＬ的表达呈年龄相关的变化；胸腺、淋巴结和ＰＢＬ都有ＧＨ合成细胞，且ＧＨ缺乏患儿与正常人无异；ＩＧＦｓ多肽、受体和结合蛋白基因在儿童胸腺和淋巴结均有不同水平的表达，提示它们在免疫器官局部以自分泌或旁分泌的形式产生和发挥作用。结论ＧＨＩＧＦ对于影响和调节小儿免疫系统发育具有重要意义 Objective To study the regulatory effect of growth hormone (GH) and insulin-like growth factor (IGFs) on immune system in infants and its mechanism. METHODS: The GH and its receptor (GHR) and IGF-1 (IGF-1) were systematically observed by protein expression and / or gene expression using radioimmunoassay, nucleic acid hybridization and immunohistochemistry. Receptor (IGF  IR,  IR) and binding protein (IGF  BP1  6) in children with peripheral blood lymphocytes (PBL), thymus and lymph node expression, distribution and regulation. Results The expression of GHR in PBL showed age-related changes. There were GH-synthesized cells in the thymus, lymph nodes and PBL, and GH-deficient children were no different from those in normal subjects. The IGFs, receptors and binding proteins were expressed in thymus and lymph nodes of children Different levels of expression, suggesting that they are in local immune organs in an autocrine or paracrine form and play a role. Conclusions GH-IGF is important for influencing and regulating the development of children’s immune system