慢性阻塞性肺疾患与吸烟或吸入各种污染物有关。慢性阻塞性肺疾患如肺气肿对吸入污染物更为敏感。动物吸入核素的剂量-效应研究有助于对人吸入核素的生物效应的估计,有肺疾患存在的机体将改变核素在肺中的沉积、分布和滞留,从而改变辐射剂量与生物效应。肺气肿的模型可用气管内注入弹性硬蛋 Chronic obstructive pulmonary disease and smoking or inhalation of various pollutants. Chronic obstructive pulmonary disease such as emphysema is more susceptible to inhalation of contaminants. Dose-effect studies of animal inhaled nuclides can contribute to the estimation of the biological effects of human exposure to nuclides, and the presence of an organism with a lung condition will alter the deposition, distribution and retention of nuclides in the lungs, altering the radiation dose and biological effects . Emphysema model can be injected intratracheal elastic eggs