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对500名健康人群行乙肝疫苗免疫三针后,用ELLSA法检测其抗HBs,结果表明:一、三年后成人组阳转率最高、儿童组次之、老年组最低,差别显著(P<0.01)。三年后三组阳转率都增高,但成人组及儿童组显著(P<0.01)。老年组不显著(P>0.05)。五年后阳转率均降低,以儿童组最显著(P<0.01),成人组仍为81.7%。本文认为上述反映了人群免疫状态的差异。因此,再次加强免疫青壮年人可推迟至五年以后,儿童可于三年左右,对老年人可持续加强免疫、直至阳转。
After three doses of hepatitis B vaccine were immunized in 500 healthy people, the anti-HBs were detected by ELLSA. The results showed that the highest positive rate was found in the adult group one to three years later, followed by the children group, the lowest in the elderly group (P < 0.01). After three years, the positive rates of three groups increased, but the scores of adults and children were significantly higher (P <0.01). The elderly group was not significant (P> 0.05). After five years, the positive rate decreased, the most significant in children (P <0.01), still 81.7% in the adult group. This paper argues that the above reflect the difference in population immune status. Therefore, to re-energize young adults who are immunized again can be postponed to five years later, the children can have a sustained and vigorous immunization against the elderly for about three years until they have achieved positive results.