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为了探讨和评估Tenascin和CD34表达与人脑胶质瘤侵袭和预后的相关性 ,采用免疫组织化学和原位杂交方法 ,对 35例不同级别人脑胶质瘤组织的Tenascin及CD34表达进行检测 ,并根据患者术后随访结果进行相关性分析。结果显示 ,不同病理级别的胶质瘤胞浆内Tenascin表达或微血管密度 (MVD)具差异有显著性意义 ,随肿瘤病理级别增高 ,Tenascin表达和MVD密度越高 ,两者有显著相关性 (P <0 0 1)。Kaplan Meier生存曲线表明 ,Tenascin表达或MVD密度与人脑胶质瘤患者预后呈显著相关 ,高表达Tenascin且血管密度较高的患者预后较差。提示Tenascin及CD34与胶质瘤的侵袭性生长有关 ,检测两者对判断肿瘤患者预后有重要参考价值。
In order to investigate and evaluate the relationship between Tenascin and CD34 expression and the invasion and prognosis of human glioma, the expression of Tenascin and CD34 in 35 different grades of human glioma was detected by immunohistochemistry and in situ hybridization. According to the results of follow-up of patients, the correlation analysis was carried out. The results showed that there were significant differences in the expression of Tenascin or microvessel density (MVD) in different pathological grades of glioma cytoplasm. With the increase of tumor pathological grade, Tenascin expression and MVD density were significantly correlated (P <0 0 1). Kaplan Meier survival curves showed that Tenascin expression or MVD density was significantly associated with the prognosis of human glioma patients. Patients with high expression of Tenascin and high blood vessel density had a poorer prognosis. It is suggested that Tenascin and CD34 are involved in the aggressive growth of glioma. The detection of them both has an important reference value for judging the prognosis of patients with cancer.