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免疫佐剂的研究历史很长,从弗氏佐剂开始,广泛地应用革兰氏阴性杆菌内毒素(LPS)、百日咳杆菌等菌体及其菌体成分、氢氧化铝等无机物质作为佐剂。早在1930年Freund报告了弗氏不完全佐剂(FIA),系按85:15的比例在矿物油中混入Arlacel A(注:一种含单油酸二缩甘露醇的商品名mannide mono cleate)制成
Immune adjuvant research has a long history, starting from Freund’s adjuvant, widely used gram negative bacilli endotoxin (LPS), Bordetella pertussis and other bacteria and cell components, aluminum hydroxide and other inorganic substances as an adjuvant . As early as 1930, Freund reported incomplete Freund’s adjuvant (FIA) mixed with Arlacel A in mineral oil at a ratio of 85:15 (Note: A mannide mono cleate containing monooleate mannide mono cleate )production