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作者对23例肾癌病人作了细胞染色体检查并对这些结果的意义与临床、病理学的关系进行讨论。 23例肾癌病人中,21例单纯性肾细胞癌,2例为Von Hippel-Lindau病合并肾癌。除2例为颗粒细胞癌外,其余21例为透明细胞癌。21例肾细胞癌中19例有克隆性染色体异常,21例中有11例出现3号染色体3P的缺失或重排,然后是7号三体性(7例),接下去的顺序为-6/69-(5例)-Y(5例),-17/17q-(5例),-14(4例)和-18(4例)。在11例3号染色体(3P)异常中,2例全缺失4例部分缺失,2例内翻,3例不平衡转位。在这11例中,有5例出现3P结构异常,包括在3P12-3P14间出现脆性位点或3P14-3P21区缺失。2例Von Hippel-Lindau病合并肾癌的染色体核型未发现异常。
The authors performed a chromosomal examination of 23 patients with renal cell carcinoma and discussed the relationship between these findings and clinical and pathological features. Twenty-three of 23 renal cell carcinoma patients had simple renal cell carcinoma and 2 had Von Hippel-Lindau disease with renal cell carcinoma. In addition to 2 cases of granular cell carcinoma, the remaining 21 cases of clear cell carcinoma. Twenty-nine of the 21 renal cell carcinomas had a clonal chromosomal abnormality, 11 of 21 had a 3P deletion or rearrangement on chromosome 3, followed by a trisomy 7 (7), followed by a sequence of -6 / 69- (5) -Y (5), -17 / 17q- (5), -14 (4) and -18 (4). Among the 11 cases of chromosome 3 (3P) abnormalities, 2 cases were partially deleted, 4 cases were partially deleted, 2 cases were inverted and 3 cases were unbalanced transposition. In these 11 cases, 5 cases showed 3P structural abnormalities including the presence of a fragile site or a deletion of the 3P14-3P21 region between 3P12-3P14. Two cases of Von Hippel-Lindau disease with renal cell carcinoma showed no abnormal karyotype.