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目的探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)分娩时机及方式对母儿结局的影响。方法对228例ICP病例进行回顾性研究,分析ICP患者终止妊娠的时机及方式与母儿结局的关系。结果重度ICP组早产儿、低体重儿、羊水粪染、新生儿窒息率显著高于轻度ICP组(P<0.05);轻度ICP组孕37~40周阴道分娩与剖宫产比较母儿结局无差异(P>0.05)。结论轻度ICP患者孕37~40周阴道分娩为宜;重度ICP患者胎肺成熟后以选择性剖宫产终止妊娠为宜。
Objective To investigate the timing and delivery of intrahepatic cholestasis of pregnancy (ICP) during maternal and neonatal outcomes. Methods A retrospective study of 228 patients with ICP was conducted to analyze the relationship between termination of pregnancy and timing and manner of ICP patients. Results Compared with mild ICP group, the incidence of asphyxia in preterm infants, low birth weight infants and meconium-stained amniotic fluid in severe ICP group was significantly higher than that in mild ICP group (P <0.05). Compared with cesarean section in mild ICP group No difference in outcome (P> 0.05). Conclusions Mild ICP patients should be given vaginal delivery 37 to 40 weeks pregnant. It is advisable to terminate pregnancy by selective cesarean section after severe fetal lung injury in ICP patients.