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设计合成了N-(取代苯甲酰氨基)脲衍生物(取代基=p-OC2H5,H,p-Cl)1～3,应用吸收光谱法考察了受体分子与阴离子如CH 3 CO-2,F-,H 2 PO-4等的相互作用,考察了取代基对受体分子与阴离子亲合力和结合选择性的调控或改善能力.结果表明,该类受体分子与阴离子通过氢键形成阴离子配合物,乙腈中受体分子1对F-表现出极高的响应选择性.Job作图法表明1与F-的结合计量比为1∶1,1H NMR滴定结果为受体分子与阴离子间的氢键作用本质提供了直接证据,初步探讨了F-响应选择性的原因.
The N- (substituted benzoylamino) urea derivatives (substituent = p-OC2H5, H, p-Cl) 1 ~ 3 were designed and synthesized. The interaction between the acceptor molecule and anion such as CH 3 CO-2 , F-, H 2 PO-4, etc. The effects of substituents on the affinity and binding selectivity of the acceptor molecule to the anion were investigated. The results showed that the acceptor molecule and the anion were formed by hydrogen bonding The anion complex, Acetonitrile, showed a very high selectivity for F-, and the Job mapping method showed that the binding ratio of 1 to F- was 1: 1, and the 1H NMR titration result was that the acceptor molecule and anion The nature of the hydrogen bonding between the two provides direct evidence to initially explore the reasons for the F-response selectivity.