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Howells等(1981)报告,将乙胺嘧啶装入硅胶囊或混合于硅胶赋形剂制成的缓释植入剂,埋入小鼠的皮下,对伯氏鼠疟原虫感染的防御作用可长达5～6个月。但在释完后需经手术再取出残留部分,这就限制了该种缓释植入剂在疟区的推广使用。本文选用生物降解的多聚体制成乙胺嘧啶、磺胺嘧啶和环氯胍的缓释植入剂,对小鼠感染疟原虫后的抗疟效果进行了实验观察。选用的生物降解多聚体为“双氢吡喃”,即3,4-双氢-2H-吡喃-2-甲基(3,4-双氢-
Howells et al. (1981) reported that pyrimethamine was loaded into a silicone capsule or a slow release implant made of a silica gel excipient and embedded in mouse skin for a long defensive effect against P. berghei infection Up to 5 to 6 months. But after the release of the need to be surgically removed and then the residual part, which limits the kind of sustained release implants in the promotion of the use of malaria area. In this paper, biodegradable polymers made of pyrimethamine, sulfadiazine and cycloguanidine sustained-release implants, anti-malarial effect of mice infected with malaria was observed experimentally. The biodegradable polymer used is “dihydropyran”, 3,4-dihydro-2H-pyran-2-methyl (3,4-