培养在含BrdU培养液中的淋巴细胞,最近又证实一个新的可遗传的常染色体脆性位点在10号染色体长臂2区5带(10q25)。Sutherland等认为这个脆性位点既不受叶酸存在与否的限制,也不受培养液pH变化的影响。这是在没有表型效应杂合子(携带者)1/30的澳大利亚人群中发现的。Scheres和Hustinx曾报导过一个智力低下13岁的女 The culturing of lymphocytes in BrdU-containing broth has recently demonstrated that a new heritable autosomal fragile site is located on the 2nd, 5th, and 5th bands of the long arm of chromosome 10 (10q25). Sutherland so that the fragile sites neither by the presence of folic acid or not, is not affected by changes in the pH of the broth. This is found in an Australian population without a phenotypic effector heterozygote (carrier) 1/30. Scheres and Hustinx have reported a 13-year-old woman with mental retardation