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锂盐在躁郁症中的广泛应用增加了锂中毒的发生率。早期治疗有效浓度1.5毫克当量/升以内与中毒浓度1.6毫克当量/升以上之间距离很小,但以后治疗可维持较低浓度,即0.3～0.8毫克当量/升。老年病人,肾功能损害的发生率增高、肾对锂的廓清率降低是造成锂中毒的重要有关因素之一。本文报告二例虽经透析疗法无效的永久性神经系统损害。例一,50岁女性,开始用碳酸锂日量800毫克,两日后日量增至1600毫克,次日增至2400毫克,后仍减至1600毫克/日,共服药9日入院。入院前三天患者嗜睡、恶心、呕吐,继续服药,次日即深睡,共济失调,行走困难。入院时已呈昏睡,对痛刺激仅有张眼反应,出现三次癫痫发作,全身腱反
The widespread use of lithium salts in bipolar disorder has increased the incidence of lithium poisoning. Early treatment effective concentration of 1.5 mg eq / L and poisoning concentration of 1.6 mg eq / L above the distance between the small, but the treatment can be maintained at a lower concentration, that is, 0.3 to 0.8 mg equivalent / liter. Elderly patients, increased incidence of renal damage, kidney clearance rate of lithium is reduced lithium poisoning is one of the important factors. This article reports two cases of permanent nervous system impairment that are ineffective by dialysis. For example, a 50-year-old woman started to use 800 mg of lithium carbonate daily for two days and increased to 1600 mg two days later. She increased to 2,400 mg the next day and then reduced to 1,600 mg once daily for a total of 9 days. Patients drowsiness, nausea, vomiting three days before admission, continue to take medicine, deep sleep the next day, ataxia, difficulty walking. Admission has been lethargic, only painful eye irritation reaction, there were three epileptic seizures, systemic tendon