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目的观察肾衰宁颗粒对慢性肾功不全患者肾功能及脂质代谢的影响。方法 240例确诊为慢性肾功不全的患者在基础治疗基础上给予肾衰宁颗粒15-40g/d,于治疗前和治疗后12周分别检测血清CHO、TG、HDL-C、LDL-C、Scr和BUN的浓度。结果 CRF-2、CRF-3期患者治疗前较治疗后血清BUN、Scr水平明显下降(P<0.05或P<0.01),CRF-1、2、3期患者治疗前后各项指标(CRF-3期患者的HDL无明显改变)比较差异有显著性(P<0.05或P<0.01)。结论肾衰宁颗粒能够明显降低早中期CRF患者的尿素氮和肌酐值,能部分改善CRF患者的脂质代谢。
Objective To observe the effect of Shenshuaining granule on renal function and lipid metabolism in patients with chronic renal insufficiency. Methods 240 patients diagnosed as chronic renal insufficiency were given Shennianning Granules 15-40g / d on the basis of basic treatment. Serum CHO, TG, HDL-C and LDL-C levels were measured before treatment and 12 weeks after treatment. Scr and BUN concentrations. Results The levels of serum BUN and Scr in patients with CRF-2 and CRF-3 before treatment were significantly lower than those before treatment (P <0.05 or P <0.01). CRF-3 No significant change in HDL patients) was significantly (P <0.05 or P <0.01). Conclusion Shenshuaining granule can significantly reduce the levels of urea nitrogen and creatinine in early and middle CRF patients, and can partially improve lipid metabolism in CRF patients.