伐尼克兰作为一种专门针对成人戒烟的处方药在中国上市已经8年有余。临床实践中伐尼克兰戒烟的有效性已经得到广泛肯定,对其安全性的研究,近年也取得了更深入的发展,在新研究成果的支撑之下,欧美已先后取消伐尼克兰安全警告标签。本文综述了伐尼克兰戒烟有效性及安全性的相关文献,以期澄清用药疑虑,促进合理用药,提高戒烟成功率。 Varenicline has been in the market for more than eight years as a prescription drug specifically for adults who quit smoking. In clinical practice, the effectiveness of varenicline smoking cessation has been widely acknowledged. The study on its safety has also made further development in recent years. Under the support of new research results, Europe and the United States have successively canceled the varenicline safety warning label . This article reviews the literature about the effectiveness and safety of varenicline smoking cessation, with a view to clarifying drug use concerns, promoting rational drug use and increasing the success rate of smoking cessation.