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目的:探讨蛋白酶体功能障碍及其所致的路易(小)体形成对散发性帕金森病发病机制的影响效果,为明确散发性帕金森病发病机制提供可靠依据。方法:研究组给予蛋白酶体抑制剂注射;对照组给予生理盐水注射。指定具有专业知识及丰富经验的相关技术人员完成两组大鼠本次实验过程。记录路易(小)体形成率及黑质部位α-Sun蛋白表达情况,给予统计学分析后得出结论。结果:研究组α-突触核蛋白(α-Syn)与β-肌动蛋白(β-actin)比值显著高于对照组(P<0.05);两组大鼠实验前路易(小)体形成率对比结果无统计学意义(P>0.05),经不同方法处理后研究组路易(小)体形成率(94.00%)显著高于对照组(4.00%)及本组实验前(2.00%)(P<0.05)。结论:蛋白酶体功能障碍是导致α-Syn聚集及路易(小)体形成的主要原因,也是发生散发性帕金森病的危险因素,应引起相关医护工作者高度重视。
Objective: To investigate the effect of proteasome dysfunction and the formation of Lewy bodies on the pathogenesis of sporadic Parkinson’s disease, and to provide a reliable basis for elucidating the pathogenesis of sporadic Parkinson’s disease. Methods: The study group was given proteasome inhibitor injection; the control group was given saline injection. Designated with relevant expertise and rich experience in related technical personnel to complete the two groups of rats in this experiment. Record the formation rate of LS and the expression of α-Sun protein in the substantia nigra, and give the conclusion after statistical analysis. Results: The ratio of α-Syn to β-actin in the study group was significantly higher than that in the control group (P <0.05). Before the experiment, (P> 0.05). The rate of formation of small body of the study group after treatment by different methods (94.00%) was significantly higher than that of the control group (4.00%) and the group before the experiment (2.00%) ( P <0.05). Conclusions: Proteasome dysfunction is the main reason leading to the accumulation of α-Syn and the formation of Lewy bodies. It is also a risk factor for sporadic Parkinson’s disease, which should be paid great attention to by related health care workers.