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本文对35例特发性侏儒症病人作了GRF兴奋试验,同时合用三种经典兴奋试验(L-Dopa、精氨酸、深睡眠),并观察连续应用GRF1周后对“经典”GH兴奋试验反应的影响。观察到21例经典兴奋试验属垂体性侏儒者,9例对GRF试验为敏感和极敏感反应,提示有相当多的侏儒症患者病变不在垂体而在下丘脑。8例GH完全缺乏患者(三项经典试验GH峰值均<5μg/L)者,经连续注射GRF1周后,重复经典试验发现其中1例恢复正常,提示此例侏儒症可能属下丘脑性(较重型)。结合文献本文初步提出了一种生长激素缺乏症的分型法。
In this paper, 35 patients with idiopathic dwarfism were made GRF stimulation test, combined with three classic excitement test (L-Dopa, arginine, deep sleep), and observed after continuous application of GRF 1 week after the “classic” GH excitement test The impact of the reaction. 21 cases of classical excitatory test were observed pituitary dwarf, 9 cases of GRF test for sensitive and highly sensitive reaction, suggesting that a considerable number of dwarfism patients with pituitary lesions not in the hypothalamus. Eight patients with GH deficiency were completely lacking (GH of three classic trials all <5μg / L). One week after repeated injections of GRF after one week of continuous injection of GRF, one case returned to normal, suggesting that dwarfism may be hypothalamus in this case Heavy). Combined with the literature initially proposed a method of classification of growth hormone deficiency.