巴比妥类药物常用作镇静、安眠剂.有的也可作麻醉用。使用过量时可引起中毒,严重者可出现昏迷,呼吸抑制,甚至死亡。体内过程口服易自胃肠道吸收,进入血液循环后,迅速分布于全身各组织及体液中,其中以血浆浓度最高,肝、肾、脑组织次之.也可渗过胎盘分布于胎儿的各组织。由于其脂溶性的强弱不同,它们进入脑组织的快慢也各异。脂溶性强的易进入脑组织,产生作用 Barbiturates are often used as sedatives, hypnotics, and some can also be used for anesthesia. When used in excess can cause poisoning, severe coma may occur, respiratory depression, and even death. In vivo process oral easily absorbed from the gastrointestinal tract, into the blood circulation, the rapid distribution in the body tissues and body fluids, of which the highest plasma concentration, followed by liver, kidney and brain tissue can also be distributed across the placenta in the fetus organization. Due to their different fat-soluble strength, their speed into the brain tissue also vary. Fat-soluble and easy to enter the brain, have a role