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目的对比研究2种不同苦参碱自纳米乳化制剂肠淋巴转运差异。方法采用大鼠三重在体单向肠灌流(T-SPIP)实验,以苦参碱原药为参比,利用乳糜流动阻断剂(秋水仙碱),对比研究2种不同苦参碱自纳米乳化制剂在大鼠不同肠段淋巴吸收特性的差异。结果自乳化制剂粒径小且分布均匀,在大鼠的不同肠段均有较高吸收,苦参碱磷脂复合物自纳米乳化制剂(MPC-SN)在回肠段渗透系数最高,且受乳糜流动阻断剂的影响最大。结论自乳化制剂可通过肠淋巴通道增加药物吸收。脂溶性高且粒径较小的苦参碱-磷酸复合物自乳化纳米粒(MPC-SN)更易经肠淋巴系统转运。
Objective To compare the differences of intestinal transport between two different matrine self-nanoemulsion preparations. Methods T-SPIP in rats was used in this study. Matrine was used as the reference and chylinergic flow blocker (colchicine) was used to compare two different matrine self-nano Difference of lymphatic absorption characteristics of different emulsifying agents in different intestine of rats. Results The self-emulsifying preparation had small particle size and uniform distribution and had higher absorption in different intestinal segments of rats. MPC-SN of matrine phospholipid complex had the highest permeability coefficient in the ileum and was affected by chyle flow Blockers have the biggest impact. Conclusion Self-emulsifying agents increase drug absorption through intestinal lymph channels. Matrine-phosphate complexes self-emulsifying nanoparticles (MPC-SN), which are fat-soluble and have a small particle size, are more likely to be transported via the intestinal lymphatic system.