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目的探索性激素水平变化是否存在民族、性别差异;性激素水平、空腹胰岛素与血尿酸的相关性,为临床疾病预防提供依据。方法选取长期居住在宁夏城市地区60岁以上社区人群共566例,回族180人,汉族386人。检测血清睾酮(T)、雌二醇(E2)与性激素结合球蛋白(SHBG)、空腹胰岛素(INS)、血尿酸(UA)进行分析。结果 60岁以上男性汉族血尿酸水平随龄有升高趋势(F=2.810,P<0.05);各年龄组比较显示,男性汉族60~与65~、70~、75~岁年龄组比较差异均有统计学意义(P均<0.05);不同民族、性别调查者尿酸检出率无明显差别(P>0.05);回族男、女性尿酸水平随睾酮下降而升高(P<0.05);汉族女性血尿酸水平随空腹胰岛素升高而下降(P<0.05);男性尿酸值>420μmol·L-1组较尿酸值<420μmol·L-1组高血脂、结石及痛风的发生率升高(P<0.05)。结论宁夏地区男性汉族人群血尿酸均数随年龄增长有升高趋势;回族男、女尿酸与睾酮、汉族女性尿酸与空腹胰岛素存在相关性;尿酸升高可影响高血脂、肾结石等相关疾病的发生率。
Objective To explore whether sexual and gender differences exist in the changes of sexual hormone levels, and the correlation between sex hormone level, fasting insulin and serum uric acid, so as to provide basis for clinical disease prevention. Methods A total of 566 community residents over the age of 60 in Ningxia urban area were selected, including 180 Hui people and 386 Han Chinese people. Serum testosterone, estradiol and SHBG, INS and UA were measured. Results The level of serum uric acid in Han nationality over 60 years old increased with age (F = 2.810, P <0.05). The comparison of each age group showed that there was significant difference between 60-65, 70-, 75- (P <0.05). There was no significant difference (P> 0.05) in the detection rate of uric acid among different ethnic groups and gender groups. The levels of uric acid in male and female were increased with the decrease of testosterone (P <0.05) The level of serum uric acid decreased with the increase of fasting insulin (P <0.05). The incidence of hyperlipidemia, stone and gout were higher in male with uric acid> 420μmol·L-1 than those with uric acid <420μmol·L-1 (P < 0.05). Conclusions The average serum uric acid in Ningxia Han population tends to increase with age. There is a correlation between uric acid and fasting insulin in male and female uric acid, testosterone and Han nationality in Han nationality. Hyperuricemia may affect hyperlipidemia, kidney stones and other related diseases Occurrence rate.