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大量的细胞学和阴道内窥镜研究表明,女性下生殖道早期浸润癌是由局灶性的上皮内肿瘤(intraepithelial neoplasia)发展而来的;而上皮内肿瘤的恶变可能是致瘤因子作用于生殖道上皮(如化生的宫颈上皮)而引起的。流行病学研究表明:杂乱的性生活和传染性性病在下生殖道发生癌前病损和癌变时可能起重要作用。由此推论,致癌物可能通过性交传播,其中就有几种传染性微生物,如HSV-2和HPV。以前认为,单纯疱疹二型病毒(HSV-2)可能诱发女性下生殖道肿瘤
A large number of cytological and vaginal endoscopy studies have shown that women with early invasive carcinoma of the lower genital tract develop from focal intraepithelial neoplasia; whereas malignancy of intraepithelial neoplasia may be caused by oncogenic factors Reproductive tract epithelium (such as metaplasia of the cervix) caused. Epidemiological studies have shown that: Messy sex and infectious diseases in the lower genital tract pre-cancerous lesions and carcinogenesis may play an important role. As a corollary, carcinogens can be transmitted through sexual intercourse, among which are several infectious organisms such as HSV-2 and HPV. Previously, herpes simplex virus type 2 (HSV-2) may induce female genital tract tumors