药物-药物相互作用药动学相互作用非甾体抗炎药有许多都是有机酸类,蛋白结合率极高(见表),故能从结合部位置换其他紧密结合的有机酸类。例如,甲灭酸、保泰松及水杨酸盐可置换香豆素类抗凝剂;保泰松及水杨酸又可置换苯妥英钠或甲苯磺丁脲。但须注意,虽然非甾体抗炎药蛋白结合率都很高,但某些非甾体抗炎药能从蛋白结合部位取代华法林,而消炎痛则不能,因而无法预料。 Drug-Drug Interactions Pharmacokinetic Interactions There are many non-steroidal anti-inflammatory drugs that are organic acids with a high protein binding rate (see table), so that other tightly bound organic acids can be displaced from the binding site. For example, mefenamic acid, phenylbutazone and salicylates can replace coumarin anticoagulants; phenylbutazone and salicylic acid can replace phenytoin sodium or tolbutamide. However, it should be noted that although NSAIDs have high protein binding rates, some NSAIDs can replace warfarin from protein-binding sites, while indomethacin can not and therefore can not be predicted.