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在改良的副肾皮激素中疗效最强而无钠素保留副作用者首推Dexamethasone(Ⅰa)和Triamcinolone(Ib)。鉴于9α-氟可的唑的疗效虽比可的唑大十倍,而其纳素保留副作用也相应增加,可见Ⅰa和Ⅰb副作用的消失是由于C_(16)的α位置的取代基的存在。作者之一与其同工作者曾将易从薯蓣配基(diosgenin)制成的16α,17α-环氧化合物Ⅱa以Wolff改良法制成得量颇佳的16α-羟基化合物Ⅲa,这种破断16α,
Dexamethasone (Ia) and Triamcinolone (Ib) are among the most potent in improving subanodermatotropin without any side effects of sodium retention. Although the efficacy of 9α-fluocortolizumab was ten times greater than that of canzole and the corresponding side effects of its retention of its receptors were also increased, the disappearance of the side effects of Ia and Ib was due to the presence of the substituent at the alpha position of C_ (16). One of the authors and his colleagues used 16ol-17a-epoxy compound IIa, which is readily made from diosgenin, to obtain a fairly good 16α-hydroxy compound IIIa by Wolff’s modification. This method of breaking 16α,