论文部分内容阅读
目的:探讨成人支气管哮喘患者变应原分布特点及SIgE与IL-2血清蛋白表达的相关性。方法:收治哮喘患者67例和同期健康体检者60例,进行变应原检测,同时检测IL-2、SIgE血清蛋白表达。结果:67例哮喘患者系统变应原过筛总阳性率94%,其中吸入变应原阳性率69.4%,食物变应原阳性率30.6%,艾蒿和树木组合(柳树/杨树/榆树)是最主要和最强烈的变应原,吸入变应原的致敏性较食物变应原强。哮喘组IL-2、SIgE血清蛋白表达与对照比较,差异有统计学意义(P<0.05),SIgE与IL-2血清蛋白呈负相关。结论:在过敏因素中,吸入性变应原是诱发支气管哮喘的主要因素,而艾蒿、树木组合(柳树/杨树/榆树)等又是吸入变应原中的主要变应原,特异性变应原能促进SIgE的分泌,IL-2可能抑制SIgE。
Objective: To investigate the distribution of allergen and the correlation between SIgE and IL-2 serum protein in adult patients with bronchial asthma. Methods: Sixty-seven asthma patients and 60 healthy subjects were enrolled in this study. Allergen detection was performed. Serum IL-2 and SIgE protein levels were also detected. Results: The total positive rate of allergic system screening was 94% in 67 patients with asthma, of which the positive rate of inhalation allergen was 69.4% and the food allergen positive rate was 30.6%. The combination of Artemisia arborescens and tree combinations (willow / poplar / elm) Is the most important and most intense allergens, inhaled allergens allergic than food allergens strong. Serum protein expression of IL-2 and SIgE in asthma group was significantly lower than that in control group (P <0.05), but negatively correlated with serum IL-2 and SIgE. Conclusion: Allergenic factors, inhalation allergen is the main factor inducing bronchial asthma, and Artemisia, tree combinations (willow / poplar / elm) is the main allergen inhaled allergen, specificity Allergens can promote the secretion of SIgE, IL-2 may inhibit SIgE.