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用卫生部武汉生物制品研究所生产的血源加热灭活乙型肝炎（乙肝）疫苗６μｇμｇ和１０μｇ全程免疫３～６岁幼儿，免疫后１个月采血检测，其血清抗－ＨＢｓ阳转率为９８１８％，９８１４％，Ｓ／Ｎ平均值为１０１６６，１１３６９。而每剂含１２μｇ的三步化学灭活血源乙肝疫苗，全程免疫后１个月抗－ＨＢｓ阳转率为９８８１％，Ｓ／Ｎ平均值为７９０９，明显低于加热灭活疫苗６μｇ组（Ｐ＜００５）和１０μｇ组（Ｐ＜００１）。说明加热灭活乙肝疫苗免疫原性更好，且免疫剂量、价格均可降低，这将更有利于在广大农村地区推广使用。本次共观察４１０名３～６岁儿童，接种两种不同灭活方式的血源乙肝疫苗后，仅个别儿童接种部位稍有疼痛感，未见发热及局部红晕反应，全程免疫后１个月检测ＨＢｓＡｇ、抗－ＨＢｃ均阴性，证明两种血源疫苗均安全全可靠。
With the Ministry of Health, Wuhan Institute of Biological Products produced by heating the Hepatitis B (Hepatitis B) vaccine inactivated by Hepatitis B (hepatitis B) vaccine and 10μg whole-immune 3 to 6-year-old children, 1 month after immunization blood tests, the serum anti-HBs positive rate 98.18% and 98.14% respectively, and the S / N average was 101.66 and 113.69. Each dose of 12μg three-step chemical inactivated blood-borne hepatitis B vaccine, anti-HBs positive conversion rate was 9881% and the S / N average was 7909 at 1 month after the whole immunization, which was significantly lower than that of heat inactivation Vaccine 6μg group (P <005) and 10μg group (P <001). This shows that the heat-inactivated hepatitis B vaccine has better immunogenicity, and the immunization dose and the price can be reduced, which will be more conducive to the promotion and use in the vast rural areas. The total observed 410 children aged 3 to 6 years, inoculated with two different ways of inactivation of blood-borne hepatitis B vaccine, only a few children vaccinated site a little pain, no fever and partial flush reaction, one month after the full immunization Detection of HBsAg, anti-HBc were negative, proving that both blood-borne vaccines are safe and reliable.