双膦酸盐(Bisphosphonates,BPs)是用于各类骨疾患及钙代谢性疾病的一类新药物。能特异的与骨质中的羟膦灰石结合,抑制破骨细胞活性,从而抑制骨质吸收。习惯上,依其作用强度或上市时间,人们将BPs分为三代。第一代系不含氮的BPs,第一个用于临床的是依替膦酸钠(Etidronate)。由于 Bisphosphonates (BPs) are a new class of drugs used in various bone disorders and calcium-related disorders. Can be specific and bone in the hydroxyapatite binding, inhibition of osteoclast activity, thereby inhibiting bone resorption. Habitually, BPs are divided into three generations, depending on the strength of their effect or time to market. The first generation of non-nitrogen-containing BPs, the first for clinical use is Etidronate (Etidronate). due to