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目的:分析结直肠癌患者红细胞分布宽度(RDW)和平均血小板体积(MPV)升高的相关性.方法:分析2016-01—2017-11武汉协和医院确诊结直肠癌患者142例作为研究对象,并以同期疑似症状但排除结直肠癌患者176例作为对照组1,健康体检者199例作为对照组2.结果:结直肠癌患者RDW(14.58±2.30)％和MPV(10.75±1.10)fl均明显高于对照组1 RDW(12.84±0.61)％和MPV(9.87±1.19)fl(P＜0.01);对照组2 RDW(13.17±0.52)％和MPV(9.73±0.34)fl.且RDW和MPV在结直肠癌各分期之间差异无统计学意义(P＞0.05).RDW预测结直肠癌的ROC曲线下面积为0.816,诊断的最佳截断值为13.2％,敏感度和特异性分别为74.6％和71.6％.MPV预测结直肠癌的ROC曲线下面积为0.732,诊断的最佳截断值10.1 fl,敏感度和特异性分别为76.1％和65.9％.结论:结直肠癌患者RDW和MPV水平明显高于对照组,能够作为早期筛查结直肠癌的指标,但其对于肿瘤分期则无显著意义.“,”Objective: To analysis the relationship between red cell distribution width (RDW) and mean platelet volume(MPV) and colorectal cancer. Method: A total of 142 colorectal cancer patients as well as 176 patients with suspected symptoms but excluding colorectal cancer as control group one and 199 healthy people as control group two were selected during January 2016 to November 2017 from the union hospital in Wuhan. Result : The RDW(14.58±2.30) ％ and MPV(10.75 ± 1.10) fl were higher in colorectal cancer group than those in the controls(P＜0.05). There was no significant difference between RDW and MPV in each stage of colorectal cancer(P＞ 0.05). ROC analysis suggested that the best cutoff value of RDW was 13.2 ％ to diagnose colorectal cancer(AUC=0.816,sensitivity 74.6％ specificity 71.6％) and the best cutoff value of MPV was 10.1f(AUC=0.732, sensitivity 76.1 ％,specificity 65.9％). Conclusion:The levels of RDW and MPV in patients with colorectal、cancer were significantly higher than those in the control group and could be used as an biomarker for early screening of colorectal cancer,but no significant difference was found in the stage of cancer.