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本文报道了在原子能研究所1.2米回旋加速器上用26MeV的α粒子流轰击天然丰度的锑靶,通过~(121)Sb(α,2n)~(123)I反应,以铜基铂吸附剂对碘选择性吸附法分离和浓集~(123)I,制得Na~(123)I溶液。Na~(123)I的放化纯度大于99％。在辐照结束时,其主要放射性杂质~(124)I占产品~(123)I的比率小于1.4％,整个分离过程不到4小时即可完成,总的化学收率在95％以上。所得产品用冠醚为溶剂,对肾上腺显影剂6-碘甲基-19-去甲胆固醇以及心脏显影剂ω-~(123)I-十七烷酸进行了快速标记。结果表明,与国内外现用的标记方法相比较,该法具有快速、简便、产额高等优点。
In this paper, we report the bombardment of natural abundance antimony targets with a 26 MeV particle flow at a 1.2-m cyclotron at the Atomic Energy Institute. By means of ~ (121) Sb (α, 2n) ~ (123) Iodine selective adsorption separation and concentration of ~ (123) I, Na ~ (123) I solution was prepared. The radiochemical purity of Na ~ (123) I is more than 99%. At the end of irradiation, the ratio of ~ (124) I, the major radioactive impurity, to the product ~ (123) I is less than 1.4%. The whole separation process can be completed in less than 4 hours. The total chemical yield is over 95%. The resulting product was labeled with crown ether as a solvent and the adrenal developer 6-iodomethyl-19-nor-cholesterol and cardiac developer omega-123 (123) I-heptadecanoic acid were rapidly labeled. The results show that this method has the advantages of fast, simple and high yield compared with the current marking methods at home and abroad.