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用四种方案给新生儿接种乙肝疫苗,首次接种后12个月检查抗-HBs以观察免疫应答,HBsAg≥1:64或HBeAg阳性母亲所生婴儿随机分为两组。结果生后24h内加用HBIG者免疫应答优于单纯接种乙肝疫苗组。孕妇HBsAg情况不明者所生婴儿亦随机分为两组,二组抗-HBs的阳转率及平均几何滴度分别为82.1%,93.3%和61.6mIU/ml及112.2mIU/ml。第2、3针皮内接种小剂量乙肝疫苗能产生良好的免疫应答。
Hepatitis B vaccine was given to newborns by four schemes. Anti-HBs were inspected at 12 months after the first vaccination to observe the immune response. Infants born at HBsAg ≥1: 64 or HBeAg positive mothers were randomized into two groups. Results The immune response to HBIG was better than that of hepatitis B vaccine alone within 24 hours after birth. Infants born to pregnant women with unknown HBsAg status were also randomly divided into two groups. The anti-HBs positive rate and average geometric titers in the two groups were 82.1%, 93.3% and 61.6 mIU / ml and 112.2 mIU / ml, respectively. The second and third needle intradermal inoculation of small doses of hepatitis B vaccine can produce a good immune response.