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本文测定了40例正常孕妇、42例妊高征患者在孕晚期及产后3～4天的全血过氧化脂质(LPO)水平和红细胞超氧化物歧化酶(SOD)活性.结果:与正常孕妇对照组比较,妊高征组全血LPO水平显著升高(P<0.01),红细胞SOD活性显著降低(P<0.01),随病情加重,全血LPO水平升高及红细胞SOD活性降低更显著.本文结果提示:妊高征的发生发展与机体助氧化/抗氧化之间的平衡紊乱有一定关系.测定妊高征患者全血LPO水平有助于正确判断病情变化并指导临床治疗.
In this study, the levels of LPO and erythrocyte superoxide dismutase (SOD) in 40 normal pregnant women and 42 patients with PIH were measured in the third trimester of pregnancy and 3 ~ 4 days postpartum.Results: Compared with normal The levels of LPO in whole blood of PIH group were significantly increased (P <0.01) and the activities of SOD in erythrocytes were significantly decreased (P <0.01). With the aggravation of disease, LPO level in whole blood and SOD activity in erythrocytes decreased significantly The results suggest that the occurrence and development of PIH have a certain relationship with the imbalance of body’s oxidation / antioxidation.Detecting the LPO level of whole blood in patients with PIH will help to judge the change of disease and guide the clinical treatment.