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国内文献提示由人乳头瘤病毒(HPV)引起的生殖器疣发病率逐年增高,普查成年妇女检出率为5--10％,北医大第三医院报告1989年比1988年妇科尖锐湿疣患者成倍增长。它不仅是性传播疾病一种,而且与生殖器肿瘤有密切关系。由于临床、病理诊断标准不一致,误诊、漏诊在所难免。为使临床诊断准确简便,本文着重研究HPV感染的(1)临床和病理学诊断;(2)核酸分子杂交;(3)超微结构的变化。目的在于通过多项指标相互关系分析,证实目前在临床所观察到的尖锐湿疣确与HPV感染有密切关系;证实所用病理学诊断标准的准确性。
Domestic literature suggests that the incidence of genital warts caused by human papillomavirus (HPV) increased year by year, the detection rate of adult women in the survey was 5 - 10%, the Third Affiliated Hospital of Beijing Medical University reported in 1989 than in 1988 gynecological condyloma patients doubled increase. It is not only a sexually transmitted disease, but also closely related to genital tumors. As clinical, pathological diagnostic criteria are inconsistent, misdiagnosis, missed diagnosis is inevitable. In order to make clinical diagnosis accurate and easy, this article focuses on (1) the clinical and pathological diagnosis of HPV infection; (2) nucleic acid hybridization; (3) ultrastructural changes. The aim is to confirm that the clinically observed condyloma acuminatum is closely related to HPV infection through the correlation analysis of multiple indicators; and to confirm the accuracy of the diagnostic criteria used in the pathology.