目的 :在猪心搏骤停模型个研究复苏后轻度低温改善神经功能的分子机制。方法 :本实验使用33只近交系的五指山小型猪。未经处理的8分钟室颤后,29只存活的动物随机分为血清组(16只)和分子组(13只)。ELISA检测血清组动物复苏后0.5、6、12、24及72小时血清的TNF-α、IL-6和IL-10、MMP-9、水通道蛋白-4(AQP-4)、金属蛋白酶-1的组织抑制因子 OBJECTIVE: To study the molecular mechanism of mild hypothermia in improving the neurological function of pigs after cardiac arrest. Methods: In this experiment, 33 inbred Wuzhishan minipigs were used. Thirty-nine surviving animals were randomly divided into a serum group (16) and a molecular group (13) after untreated 8-minute ventricular fibrillation. Serum levels of TNF-α, IL-6 and IL-10, MMP-9, AQP-4 and MMP-1 at 0.5, 6, 12, 24 and 72 hours after resuscitation in serum were detected by ELISA. Of tissue inhibitor