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从甘肃岷县当归挥发油中,分离出一淡黄色油性物质,鉴定为藁本内酯,实验证明有明显的平喘作用。给豚鼠ip 0.14 ml/kg能缓解组织胺与乙酰胆碱的致喘反应,其效力约与氨茶碱50 mg/kg相仿。在豚鼠肺溢流实验,ⅳ藁本内酯0.08 ml/kg能对抗组织胺2~10 μg/kg所引起的支气管收缩。藁本内酯不仅对豚鼠离体气管条有松弛作用,而且对乙酰胆碱、组织胺以及氯化钡引起的气管平滑肌痉挛收缩,有明显的解痉作用。上述作用不能被心得安所阻断。藁本内酯对豚鼠肺、肠组织内cAMP及cGMP的含量均无明显影响。
A light yellow oily substance was isolated from the volatile oil of Danggui, Gansu, and identified as ligustilide. Experiments have shown that there is a clear anti-asthmatic effect. Giving guinea pigs ip 0.14 ml/kg can relieve histamine-acetylcholine-induced asthmatic effects, and its efficacy is about the same as aminophylline 50 mg/kg. In guinea pig lung overflow experiments, iv ligustilide 0.08 ml/kg can fight against bronchoconstriction caused by histamine 2-10 μg/kg. Ligustilide not only has relaxing effect on isolated tracheal strips in guinea pigs, but also has obvious antispasmodic effect on smooth muscle contractions of trachea caused by acetylcholine, histamine and barium chloride. The above effect cannot be blocked by propranolol. Ligustilide had no significant effect on cAMP and cGMP levels in lung and intestine of guinea pigs.