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66例至少2年无慢性排斥反应迹象的功能性同种移植物患者。其中43例接受环孢素(CycloporinA)和小剂量强的松,另23例用硫唑嘌呤和小剂量强的松维持免疫抑制治疗。如有必要可用速尿。定期测定血清肌酐和尿酸水平及24小时尿肌酐和尿酸的排泄。结果发现,环孢素组发生痛风12例(28%),硫唑嘌呤组则无1例,P<0.05。环孢素组,尤其是痛风患者,血清尿酸明显高于硫唑嘌
66 patients with functional allograft who had no evidence of chronic rejection for at least 2 years. Of these, 43 received Cycloporin A and a small dose of prednisone, and the other 23 received azathioprine and a small dose of prednisone for maintenance of immunosuppression. Use furosemide if necessary. Regular serum creatinine and uric acid levels and 24-hour urinary creatinine and uric acid excretion. In the cyclosporine group, 12 patients (28%) developed gout and 1 patient did not in the azathioprine group (P <0.05). Cyclosporine group, especially gout patients, serum uric acid was significantly higher than azathioprine