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目的探讨肿瘤坏死因子α与2型糖尿病性心脏自主神经病变的相关性。方法入选49例健康查体者及124例2型糖尿病患者为研究对象,经24小时全导动态心电图分析检测,取得相关心率变异性指标。分成NC组49例,NDCAN组55例,DCAN组69例,检测各组受试者外周血清TNF-α水平,比较各组不同指标的差异。结果DCAN组的TNF-α高于NDCAN与NC组(P<0.05)。logistic回归分析显示在校正了相关因素后,TNF-α为DCAN的独立危险因素。结论 TNF-α与糖尿病性心脏自主神经病变密切相关。
Objective To investigate the relationship between tumor necrosis factor α and type 2 diabetic autonomic neuropathy. Methods Selected 49 cases of physical examination and 124 cases of type 2 diabetes mellitus as study subjects, after 24 hours all-lead Holter analysis to detect and obtain relevant heart rate variability index. Divided into NC group, 49 cases, NDCAN group, 55 cases, DCAN group, 69 cases, test the level of TNF-α in peripheral blood of each group, and compare the differences of different indexes in each group. Results TNF-α in DCAN group was higher than that in NDCAN and NC groups (P <0.05). Logistic regression analysis showed that TNF-α was an independent risk factor for DCAN after correlating the relevant factors. Conclusion TNF-α and diabetic cardiac autonomic neuropathy are closely related.