肝硬化患者连续口服心得安能引起门静脉压持续降低。作者报告了用心得安预防肝硬化复发性胃肠出血的初步结果。24例经组织学证实的肝硬化成年患者:酒精中毒21例,乙型肝炎1例,未明原因2例。于食管胃静脉曲张破裂(17例)或急性胃糜烂(7)而产生胃肠出血后住院,这些患者还符合以下标准:①X 线所见食管静脉曲张直径≥5mm;②胃肠出血自动停止,或于食管填塞术后无复发;③无肝性脑病、腹水及黄疽,或仅于出血后暂时出现上述症状者。患者随机分为2组,每组12例。一组服安慰剂,每次1片,每天2次;另一组服心得安,其剂量以能减慢心率25%为度(40～180mg,每天2次)。上两药均于出血停止10～15天后始服用。随访3个月,凡在此期间出现出血者均停止研究并按常规治疗。结果 3个月内12例服安慰剂者5例出现胃肠出血,而12例服心得安者无1例出现胃肠出血。两组间差异显著(P=0.37)。服心得安患者未见不良副作 Continuous oral administration of propranolol in patients with cirrhosis can cause a continuous decrease in portal pressure. The authors report preliminary results of prophylaxis of recurrent gastrointestinal bleeding in patients with cirrhosis. Twenty-four adult patients with histologically confirmed cirrhosis were alcoholic in 21, hepatitis B in 2, and unexplained 2. In gastroesophageal varices (17 cases) or acute gastric erosion (7) and gastrointestinal bleeding after hospitalization, these patients also meet the following criteria: ① X-ray findings esophageal varices diameter ≥ 5mm; ② gastrointestinal bleeding stopped automatically, Or no recurrence after esophageal packing; ③ no hepatic encephalopathy, ascites and jaundice, or only after the temporary emergence of the above symptoms of bleeding. Patients were randomly divided into two groups, 12 cases in each group. A group of placebo, each 1, 2 times a day; the other group convinced, the dose can slow down the heart rate 25% (40 ~ 180mg, 2 times a day). The two drugs are bleeding stop 10 to 15 days after taking. All the patients were followed up for 3 months. All those who had bleeding during this period were stopped from the study and were treated as usual. Results In 12 patients taking placebo in 5 months, gastrointestinal bleeding was found in 12 patients, and none of the 12 patients taking progestin had gastrointestinal bleeding. There was a significant difference between the two groups (P = 0.37). Served patient no adverse side effects