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目的:探讨人乳头状瘤病毒6b(human papilloma virus6b,HPV6b)的感染与新疆哈萨克族食管癌的关系.方法:收集哈萨克族食管癌标本120例,按同性别、同民族、年龄相差小于5岁、同一个居住地选取对照120例.运用假病毒中和实验(PsV neutralization assay)检测血清中HPV6b感染率.结果:食管癌组HPV6b感染率为27.5%,对照组感染率为22.5%,两组差别无统计学意义(χ2=0.80,P=0.37).食管癌组与对照组不同性别HPV6b感染率差异均无统计学意义(χ2=0.31,0.01,P=0.58,0.92).食管癌组<50岁,50-59岁,60-69岁以及≥70岁年龄组HPV6b感染率分别为31.0%,29.0%,20.9%和35.3%,差异无统计学意义(χ2=1.67,P=0.64),对照组中分别为19.4%,13.5%,30.6%和31.3%,差异亦无统计学意义(χ2=3.93,P=0.27).结论:HPV6b感染在哈萨克族人群中普遍存在,哈萨克族食管癌的发生与HPV6b感染无相关性.
Objective: To investigate the relationship between the infection of human papillomavirus 6b (HPV6b) and Kazakh esophageal cancer in Xinjiang.Methods: A total of 120 cases of Kazakh esophageal cancer were collected, and their mean age, gender, age were less than 5 years old , The same place of residence to control the selection of 120 cases.Using PsV neutralization test (PsV neutralization assay) detection of serum HPV6b infection rate.Results: The infection rate of HPV6b in esophageal cancer was 27.5%, the control group infection rate was 22.5%, two groups The difference was not statistically significant (χ2 = 0.80, P = 0.37) .There was no significant difference in HPV6b infection rates between esophageal cancer group and control group (χ2 = 0.31,0.01, P = 0.58,0.92) The infection rates of HPV6b in patients 50 years old, 50-59 years old, 60-69 years old and ≥70 years old were 31.0%, 29.0%, 20.9% and 35.3%, respectively, with no significant difference (χ2 = 1.67, P = 0.64) The control group was 19.4%, 13.5%, 30.6% and 31.3% respectively, with no significant difference (χ2 = 3.93, P = 0.27) .Conclusion: HPV6b infection is prevalent in Kazakh population, There was no correlation with HPV6b infection.