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目的 探讨祁州漏芦对成人原发性肾病综合征脂质代谢的影响。方法 在三联治疗的基础上,118例肾病综合征患者随机分成漏芦组63例(加用漏芦)及对照组55例(不加用漏芦),并对两组病人进行了对比观察。结果 1.漏芦组治疗后4周甘油三酯(2.03±1.45)mmol/L、低密度脂蛋白(4.35±1.26)mmol/L较治疗前降低,载脂蛋白A(1.88±0.45)g/L及载脂蛋白A/载脂蛋白B(1.39±0.66)较治疗前升高(P<0.05)。2.漏芦组治疗后8周总胆固醇(7.12±1.90)mmol/L、甘油三酯(1.54±1.08)mmol/L、低密度脂蛋白(3.98±0.94)mmol/L较治疗前降低,载脂蛋白A(1.89±0.49)g/L及载脂蛋白A/载脂蛋白B(1.63±0.11)g/L较治疗前升高(P<0.05或P<0.001)。3.对照组治疗前后比较血脂无明显变化(P>0.05)。结论 祁州漏芦具有显著的降脂作用,可以改善肾病综合征病人的脂质代谢紊乱。祁州漏芦的抗氧化作用可有效地减轻脂质对肾脏的损伤。
Objective To investigate the effects of Leizhou pilchard on lipid metabolism in adult primary nephritic syndrome. Methods On the basis of triple therapy, 118 patients with nephrotic syndrome were randomly divided into three groups: 63 cases in Loulu group (plus Loulu) and 55 cases in control group (without Loulu), and the two groups of patients were compared. Results 1. After 4 weeks of treatment, triglyceride (2.03 ± 1.45) mmol / L and low density lipoprotein (4.35 ± 1.26) mmol / L were lower than those before treatment, and apolipoprotein A (1.88 ± 0.45) g / L and apolipoprotein A / apolipoprotein B (1.39 ± 0.66) were significantly higher than those before treatment (P <0.05). The levels of total cholesterol (7.12 ± 1.90) mmol / L, triglyceride (1.54 ± 1.08) mmol / L and low density lipoprotein (3.98 ± 0.94) mmol / L decreased after 8 weeks of treatment Lipoprotein A (1.89 ± 0.49) g / L and apolipoprotein A / apolipoprotein B (1.63 ± 0.11) g / L were higher than those before treatment (P <0.05 or P <0.001). The control group before and after treatment no significant changes in blood lipids (P> 0.05). Conclusion Grifola frondosa has a significant lipid-lowering effect and can improve lipid metabolism disorders in patients with nephrotic syndrome. Antioxidant effect of Gansu Loulu can effectively reduce the damage of the kidney to the lipid.