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用~(14)C-加速器质谱法(AMS)研究了香烟中尼古丁的亚硝基衍生物4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁酮(NNK)与小鼠体内血红蛋白(Hb)的加合作用,给出了加合剂量响应曲线.NNK剂量在0.01～0.1μg/kg b.w范围内,加合水平基本上是一样的;而在0.1～3.0μg/kg b.W.范围内,加合物数量与NNK剂量之间呈1g/1g表示的线性关系.同时研究发现一次性给药的NNK-Hb加合物在小鼠体内的衰减表现为快、慢两个阶段,前3天内衰减很快,3天后衰减不明显.
The nitroso derivatives of nicotine in cigarettes, 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone (NNK ) And hemoglobin (Hb) in mice to give an additive dose response curve.NNK dose in the range of 0.01 ~ 0.1μg / kg bw, the adduction level is essentially the same; and in the 0.1 ~ 3.0 μg / kg bW, the linear relationship between the amount of adduct and NNK dose was 1g / 1g.At the same time, the NNK-Hb adduct of one-time administration showed a fast and slow decay in mice Two stages, the first three days decay quickly, three days after the attenuation is not obvious.