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目的观察调强放疗联合替吉奥同期放化疗及常规放疗治疗局部晚期鼻咽癌的近期疗效和毒副反应。方法调强放疗联合替吉奥组(A组):31例,均采用6MV-X线,总剂量70Gy,放疗第1天开始口服替吉奥60mg,口服2次/d(早晚饭后口服),连续口服28d;常规放疗组(B组):32例均采用常规照射方法,6MV-X线,总剂量DT74-76Gy。结果调强放疗联合替吉奥组及常规组总有效率分别为93.6%和75%(P<0.05),毒副反应(皮肤反应、粘膜反应、骨髓抑制及口干),常规组明显高于调强放疗联合替吉奥组,且差异有显著性统计学意义(P<0.01)。结论调强放疗联合替吉奥治疗局部晚期鼻咽癌较常规放疗有很好的近期疗效,毒副反应轻,远期疗效有待进一步观察。
Objective To observe the short-term curative effect and side effects of combined intensity radiotherapy and radiotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma. Methods A total of 31 patients were treated with intensity-modulated radiotherapy (IMRT) and 6 Gy of X-ray. The total dose was 70 Gy. The first day of radiotherapy was started with 60 mg of tioglitazone orally and twice daily orally (oral administration after breakfast and dinner) , Continuous oral 28d; conventional radiotherapy group (B group): 32 cases were using conventional irradiation method, 6MV-X line, the total dose of DT74-76Gy. Results The total effective rate of combined-intensity radiotherapy combined with tirofiban and conventional group was 93.6% and 75%, respectively (P <0.05). Toxic side effects (skin reaction, mucosal reaction, myelosuppression and dry mouth) Tiaoduan radiotherapy combined with tegaserod, and the difference was statistically significant (P <0.01). Conclusion IMRT combined with TEGO treatment of locally advanced nasopharyngeal carcinoma than conventional radiotherapy have a good short-term efficacy, toxicity, long-term efficacy remains to be further observed.