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提出胎怯可以出生时低体重作为主要客观指标。分析100例胎怯新生儿,明确其病机以肾脾两虚为主。研制补肾健脾之助长口服液,治疗胎怯51例,与不用药之对照组50例相比,生长发育显著增快。临床检验患儿比正常新生儿血清T_3降低、T_4上升,经助长口服液治疗后,T_3上升、T_4下降。以出生低体重豚鼠作为胎怯动物模型,研究与“肾”、“脾”关系密切的血清促肾上腺皮质激素(ACTH)、皮质醇、生长激素、胃泌素等内分泌激素水平的关系,显示了补肾健脾法调整胎怯患儿有关激素水平、促进患儿加速生长的药理作用。
Proposed fetal fatigue can be low birth weight as the main objective indicators. Analysis of 100 cases of fetal timid newborn, clear the pathogenesis of both kidney and spleen. Development of kidney invigorating the spleen of the growth of oral liquid, treatment of fetal fatigue in 51 cases, compared with 50 cases in the control group, the growth was significantly faster. Clinical examination of children than normal neonatal serum T_3 decreased, T_4 increased by the stimulation of oral fluid treatment, T_3 increased, T_4 decreased. The low birth weight guinea pigs were used as animal models of fetal fatigue to study the relationship between serum adrenocorticotrophic hormone (ACTH), cortisol, growth hormone and gastrin and other endocrine hormones closely related to “kidney” and “spleen” Kidney and invigorating the spleen method to adjust fetal hormones related to hormone levels and promote the pharmacological effects of accelerated growth in children.