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T2DM病人随机分为A组采用口服降糖药物治疗:B组采用胰岛素与口服降糖药物交替治疗,周期为三个月,随访35个月。结果:A组中72.2%的病人单一口服二甲双胍不能使血糖达标,需加用磺脲类药物或胰岛素治疗;B组中有94.7%的病人仅口服降糖药物达标。两组病人观察35个月后,B组病人胰岛素β细胞功能有优于A组(P<0.01)。结论:胰岛素与口服降糖药物交替治疗能更好的恢复和保持β细胞分泌功能,更容易使血糖达到良好控制。
T2DM patients were randomly divided into A group treated with oral hypoglycemic agents: B group with insulin and oral hypoglycemic agents alternating treatment cycle of three months, followed up 35 months. Results: 72.2% of patients in group A received metformin alone without oral administration of sulfonylureas or insulin, and 94.7% of patients in group B only achieved oral glucose tolerance. After 35 months of observation, the function of insulin β-cells in group B was better than that in group A (P <0.01). CONCLUSION: Alternating treatment with insulin and oral hypoglycemic agents can better restore and maintain β-cell secretory function and make it easier to control blood glucose.