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作者等分别比较青霉胺、二巯基丁二酸钠(DMS)、肝豆汤、硫酸锌和BAL对尿铜排出的近期效果及其副反应。结果发现青霉胺的尿铜排出量最高,但症状改善较慢,副反应也多;DMS的尿铜排出量高、症状改善快,是较理想的驱铜药;BAL的尿铜排出量最低,近期改善率低,副反应较多。肝豆汤及硫酸锌的尿铜排出量虽较差,但副反应少,可用于不能应用青霉胺或DMS的患者;也可作为症状缓解患者或潜伏型患者的维持治疗。
The authors compared penicillamine, sodium dimercaptosuccinate (DMS), liver bean soup, zinc sulfate and BAL on urinary copper excretion of the recent effects and side effects. The results showed that penicillamine had the highest urinary copper excretion, but the symptom improvement was slower and the side reaction was more. DMS had better excretion of urinary copper and faster improvement of symptoms, which was the ideal expeller; BAL had the lowest urinary copper excretion , The recent improvement rate is low, more side effects. Liver bean soup and zinc sulfate urinary copper excretion is poor, but less side effects, can not be used for patients with penicillamine or DMS; also be used as maintenance of symptoms or patients with latent disease.