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错配修复基因hMSH2是DNA错配修复系统的重要基因,其在肿瘤发生发展中的作用已成为研究的热点。hMSH2基因多态性影响肿瘤发生的易感性;hMSH2蛋白表达的改变与多种肿瘤发生相关,并对肿瘤发生发展有一定的预测价值。
Mismatch repair gene hMSH2 is an important gene of DNA mismatch repair system, and its role in tumorigenesis has become a hot spot. hMSH2 gene polymorphism affects tumorigenesis susceptibility; hMSH2 protein expression changes associated with a variety of oncogenes, and tumor development has some predictive value.