A female patient with vaginal pain induced by multiple sclerosis was treated by acupuncture.Her chief complaint:pricking vaginal pain during intercourse for 1 year.Electroacupuncture was applied to Shènshu(肾俞BL23),Huiyáng(会阳BL35).Cìliáo(次髎 BL32)and Zhongliáo(中髎 BI.33)on lumbosacral region.The disperse wave was adopted firstly,followed by the dense wave in stimulation.The stimulation intensity was determined by the patient's tolerance.The needles were retained for 50 min totally.After 2-month treatment,the sexual function of the patient was recovered to be normal.The sexual activity was normal in 1-year follow-up and vaginal pain was not recurred.