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为研究硒与小儿肺炎发生和发展的关系,测定了57例住院肺炎患儿和85例正常儿童的血浆、白细胞中硒和谷胱甘肽过氧化物酶(GSH-Px)活性以及尿中硒含量,建立了实验动物模型,以验证和补充说明临床所得结果。结果:肺炎患儿血浆和白细胞中硒含量及GSH-Px活性均有不同程度的降低;尿中硒含量有所增加。感染支原体肺炎后,富硒组大鼠间质性肺炎的罹患率较低;给低硒组灌喂亚硒酸钠后,病情轻且病程短。说明患儿在肺炎时体内硒的消耗增多;动物实验提示:良好的硒营养状态可降低肺炎的发生率;肺炎早期补充硒,可使肺炎病情减轻且病程缩短。
In order to study the relationship between selenium and the occurrence and development of pneumonia in children, the activity of selenium and glutathione peroxidase (GSH-Px) and the content of selenium in urine of 57 hospitalized children with pneumonia and 85 normal children were measured. Content, the establishment of experimental animal models to verify and supplement the results of clinical outcomes. Results: The levels of selenium and GSH-Px in plasma and leukocyte of children with pneumonia were decreased to some extent. The content of selenium in urine increased. After infection with mycoplasma pneumonia, selenium-deficient rats had a lower attack rate of interstitial pneumonia. After sodium selenite was infused into low-selenium group, the disease was mild and the course of disease was short. Description of children with pneumonia in the body when the consumption of selenium increased; animal experiments suggest that: a good nutritional status of selenium can reduce the incidence of pneumonia; early selenium supplementation, pneumonia can reduce the severity and duration of disease.