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Background: Patients who develop fulminant myocarditis often die of sudden car diac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findi ngs that could predict the fulminant course of acute myocarditis. Methods and re sults: Thirty-five patients(mean age 28±8 years, 17 males) who had been admitt ed to intensive care unit with the diagnosis of acute myocarditis by clinical pr esentations were retrospectively recruited. They were divided into the fulminant group(n=11) and the non-fulminant group(n=24). Clinical features, laboratory d ata, and images on admission were analyzed. Overall in-hospital mortality was 1 7%(6/35). Mortality was higher in the fulminant group(45%vs. 4%, p=0.027). Mu ltivariate analysis revealed that prolongations of the QRS complex(118±27 vs. 8 8±10 ms, p=0.048) and depressed left ventricular ejection fraction(41±7%vs. 5 7±7%, p=0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortali ty of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent posi tive predictors for the development of acute fulminant myocarditis.
Background: Patients who develop fulminant myocarditis often die of sudden car diac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms / signs or laboratory findi ngs that could predict the fulminant course of acute myocarditis. Methods and re sults: Thirty-five patients (mean age 28 ± 8 years, 17 males) who had been admitt ed to intensive care unit with the diagnosis of acute myocarditis by clinical pr esentations were retrospectively recruited. They were divided into the fulminant group (n = 11) and the non-fulminant group (n = 24). Clinical features, laboratory d ata, and images on admission were analyzed. Overall in-hospital Mortality was higher in the fulminant group (45% vs. 4%, p = 0.027). Mu ltivariate analysis showed that prolongations of the QRS complex (118 ± 27 vs. 8 8 ± 10 ms, p = 0.048) and depressed left v The only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortal ty of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent posi tive predictors for the development of acute fulminant myocarditis.