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采用尾静脉注射大肠杆菌内毒素复制大鼠内毒素休克模型，检测动物血压、脑系数、海马组织一氧化氮合酶（ＮＯＳ）活性及海马ＣＡ１区形态学改变，探讨心脉灵注射液对内毒素休克大鼠的作用机理。结果显示：与病理组相比，注入心脉灵注射液后１ｈ、６ｈ，动物血压上升，脑系数下降，海马组织ＮＯＳ活性显著增高，海马ＣＡ１区神经元损伤明显减轻，动物无死亡。提示心脉灵注射液能够改善内毒素休克所致的低血压及脑水肿，保护海马ＣＡ１区神经元，增强海马组织ＮＯＳ活性，起到抗内毒素休克的作用。
The rat endotoxin shock model was established by tail vein injection of E. coli endotoxin. The blood pressure, brain coefficient, hippocampus tissue nitric oxide synthase (NOS) activity and hippocampal CA1 region morphology were detected. The mechanism of action of toxin shock rats. The results showed that compared with the pathological group, the blood pressure increased, the brain coefficient decreased, and the hippocampal tissue NOS activity increased significantly at 1 and 6 hours after injection of Xinmailing injection. Neuronal damage in the hippocampal CA1 area was significantly reduced and the animal did not die. It is suggested that Xinmailing injection can improve the hypotension and cerebral edema caused by endotoxin shock, protect the hippocampal CA1 neurons, enhance the activity of NOS in the hippocampus, and play a role in anti-endotoxin shock.